CIRC-RAPGEF5 PROMOTES INTRAHEPATIC CHOLANGIOCARCINOMA PROGRESSION BY STABILIZING SAE1 TO FACILITATE SUMOYLATION

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor prognosis.The underlying functions and mechanisms of circular RNA and SUMOylation in the development of ICC remain poorly understood.Methods Circular RNA hsa_circ_0001681 (termed Circ-RAPGEF5 hereafter) was identified by circular RNA sequencing from 19

Abstract Background Despite the numerous studies confirming the involvement of consanguinity in health problems, some populations around the world continue to practice this marital behavior.Algeria, like many Arab-Muslim countries, has very high consanguinity rates that require studies to measure the effects on public health.This study 100w product